2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. von Hippel-Lindau (VHL) Isoform

von Hippel-Lindau (VHL)

 

von Hippel-Lindau (VHL) Related Products (52):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130271
    (S,R,S)-AHPC-PEG5-COOH 2172820-14-1 99.80%
    (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG5-COOH
  • HY-103598
    (S,R,S)-AHPC-PEG3-N3 1797406-80-4 99.67%
    (S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG3-N3
  • HY-103601
    (S,R,S)-AHPC-PEG4-N3 1797406-81-5 99.93%
    (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG4-N3
  • HY-103600
    (S,R,S)-AHPC-PEG1-N3 2101200-09-1 98.18%
    (S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG1-N3
  • HY-103602
    (S,R,S)-AHPC-PEG3-NH2 hydrochloride 2097971-11-2 99.01%
    (S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG3-NH2 hydrochloride
  • HY-103604A
    (S,R,S)-AHPC-PEG4-NH2 2010159-57-4 99.51%
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2
  • HY-103599
    (S,R,S)-AHPC-PEG2-N3 2010159-45-0 99.74%
    (S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG2-N3
  • HY-128767
    VH032-PEG3-acetylene 2098799-80-3 98.14%
    VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VH032-PEG3-acetylene
  • HY-103603
    (S,R,S)-AHPC-PEG2-NH2 hydrochloride 2097973-72-1 99.77%
    (S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
    (S,R,S)-AHPC-PEG2-NH2 hydrochloride
  • HY-130798
    (S,R,S)-AHPC-amido-C5-acid 2162120-87-6 99.58%
    (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).
    (S,R,S)-AHPC-amido-C5-acid
  • HY-133487B
    (S,R,S)-AHPC-C8-NH2 2341796-79-8
    (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.
    (S,R,S)-AHPC-C8-NH2
  • HY-136163
    (S,R,S)-AHPC-C2-NH2 dihydrochloride 2341796-73-2 98.63%
    (S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.
    (S,R,S)-AHPC-C2-NH2 dihydrochloride
  • HY-130849
    (S,R,S)-AHPC-Me-C5-COOH 2229976-21-8
    (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604).
    (S,R,S)-AHPC-Me-C5-COOH
  • HY-103604
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride 2064292-52-8 98.06%
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride
  • HY-130711B
    (S,R,S)-AHPC-C3-NH2 hydrochloride 2940858-65-9
    (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-C3-NH2 hydrochloride
  • HY-103608
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl 1835705-61-7 99.89%
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
  • HY-114176B
    (S,R,S)-AHPC-C4-NH2 dihydrochloride 2341796-78-7
    (S,R,S)-AHPC-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.
    (S,R,S)-AHPC-C4-NH2 dihydrochloride
  • HY-131387
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 2409538-69-6
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736).
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
  • HY-136006B
    (S,R,S)-AHPC-C6-NH2 2306389-03-5 98.03%
    (S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-C6-NH2
  • HY-131959
    (S,R,S)-AHPC-PEG5-Boc 2923734-82-9
    (S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V.
    (S,R,S)-AHPC-PEG5-Boc